9 Mar 2022

We want to briefly discuss the concept of repeated ovulation as one of the factors responsible for ovarian cancer.
The other issues raised as helping to prevent ovarian cancer included;

  1. Use of OCP
  2. Pregnancy and lactation
  3. Fallopian tube ligation.

And conditions that have high risk for ovarian cancer includes;

  1. Nulliparous
  2. Infertility
  3. No use of OCP.

Even some commentaries are viewing ovulation events from (15 – 30)years as “useless” ovulation because according to the commentry, most women at this age range are still in school and pursuing carrier and are not ready for pregnancy. So this about 180 “useless” ovulations events (15 x 12 = 180), can be prevented by using OCP and help reduce the risk of ovarian cancer in these women!

It is uncharitable for a natural and useful event like ovulation to be termed, “useless”.

In NaProTECHNOLOGY, which is Natural – Procreative – Technology, we view natural events in reproductive health as normal until proven otherwise. We are completely certain that the notion that repeated ovulation is the cause of ovarian cancer as not the real truth of the matter. Ovulation is a complex event that is well regulated by the body. The ovarian surface epithelium (OSE) heals after every ovulation event(s). And if the healing is incomplete, or leads to malignant transformation, it happened because there was an intrinsic abnormality which was not detected and not because the ovulation events on it’s own was programmed to be defective abenitio.
Ovulation is not the only natural events in the body that involves inflammatory and anti-inflammatory events. We have the events on the skin, bone marrow, intestinal mucosa, and immune system.

So in NaProTECHNOLOGY we want to draw attention to the true picture concerning ovulation and ovarian cancer.

There are 2 (two) types of ovulation events. Namely,
(1) Normal ovulation, and (2) Abnormal ovulation.

What we hear people discuss most times is ovulation (ovulation occurred) and anovulation (ovulation did not occur).

In NaProTECHNOLOGY there is more to talk about the so called ovulation that has occurred. We ask, and anwer the question ❓, the ovulation that occurred is it normal or abnormal?

  1. Normal ovulation is defined as the rupture of matured follicle (19mm or more even with reference to woman’s age), follicular rupture difference =/> 7.5mm, and cumulus oophorus within the follicle was released at ovulation. This is anatomical diagnosis of normal ovulation verified by transvaginal ultrasound.
    Also we still went ahead to evaluate the hormonal event periovulatory estrogen, and post-ovulatory estrogen and progesterone to define the normal values based on the assumption that once a woman’s anatomical ovulation fulfils the criteria of definition just given above, then the values of periovulatory estrogen and post-ovulatory estrogen and progesterone will all be normal and standardized for future references.
  2. Abnormal ovulation is defined as anatomical ovulation events verified by transvaginal ultrasound that did not meet the defined criteria in (1) above. We have identified 5 and counting abnormal ovulation events;
  3. Matured follicle with absent cumulus (empty follicle syndrome).
  4. LUF (Luteinized un-ruptured follicle)
  5. IFS ( immature follicle syndrome)
  6. PRS ( Partial rupture syndrome)
  7. DRS ( delay rupture syndrome)
  8. BFS (big follicle syndrome) (this is yet to be universally accepted, but we already have identified it in Nigeria).

Now with these ovulation definitions clarified, we can verify the relationship between repeated ovulation and ovation cancer.

  1. Pregnancy and lactation happened because the woman had a normal ovulation. If there was abnormal ovulation it leads to abnormal pregnancies (ectopic, miscarriages). It is the normal ovulation protecting the ovaries and not the pregnancy. If the ovulation was abnormal there will be no normal pregnancy in the first place.
  2. OCP is used to prevent pregnancy mostly. It is a normal ovulation that will lead to pregnancy, therefore it is fertile women that will mostly use OCP to prevent pregnancy. An infertile woman will not need OCP. An infertile woman may have abnormal ovulation as reasons for her infertility so she will rather be looking for treatment to correct the abnormal ovulation rather than using OCP. So again, we see that in the use of OCP, that a normal ovulation is at the background. Therefore it is the normal ovulation in these OCP users that protected the ovary from cancer rather than thinking it was the OCP.
  3. Fallopian tube ligation. The same logic for OCP is true here. Tubal ligation is a method of surgical contraception. You don’t ligate the tubes of infertile women! So the tubal ligation was done because the woman was having normal ovulation. It is the normal ovulation that protected the ovary from cancer and not the tubal ligation. Note that if the tubes of fertile women are not ligated they will achieve normal pregnancy. You should not then turn round and say that the pregnancy is a protection for ovarian cancer. No! The protection for ovarian cancer is REPEATED NORMAL OVULATION!
  4. Nulliparous woman are said to be at risk of ovarian cancer. By now we know that the above statement is half truth. We should state it better by saying that women having REPEATED ABNORMAL OVULATION are at risk of ovarian cancer. If a woman is having repeated abnormal ovulation she will be Nulliparous. In other words, if a woman decided not to marry, and she is having repeated normal ovulation she is not at risk of ovarian cancer. But if a woman decided to marry or not marry, and she continues to have repeated ABNORMAL OVULATION, she is at risk of ovarian cancer.

Finally, of all the identified abnormal ovulation events diagnosed by transvaginal scan, the ovulation defects more associated with ovarian cancer included;

  1. BFS( big follicle syndrome) when the woman is rupturing follicles in non stimulated cycles bigger for size for their age.
  2. IFS (immatured follicle syndrome). When they rupture follicles less than 19mm. This ovulation defects is also associated with endometriosis.

We should start diagnosing ovulation and classifying them as normal or abnormal.

Ovulation detection with LH strip, and 21 day progesterone, and even BBT should be discouraged.

In conditions of absolute infertility like LUF(Luteinized un-ruptured follicle), the LH, Progesterone, BBT will all say she has ovulated and yet she did not even rupture the follicle. And even in IFS(immature follicle syndrome) connected with endometriosis and risk of ovarian cancer, the LH, 21 day progesterone, and BBT will all say she has ovulated but they can’t know the ovulation is defective!

And particularly, the 21 day progesterone test for ovulation may miss the ovulation events completely if the woman ovulated after day 21 in her cycle. Also if the woman early ovulation say say 8,9, or 10, collecting blood on day 21 progesterone will not accurately target the mid luteal value. The 21 day progesterone will better target mid luteal progesterone for ovulation on day 14th. From our NaProTECHNOLOGY studies in Nigeria amongst women we evaluate for infertility, ovulation on 14th day does not highest frequency of occurrence.

NaProTECHNOLOGY is a revolutionary new woman reproductive science that cooperates with the woman’s menstrual cycle using Creighton model FertilityCare System to evaluate, diagnose, and treat procreatively all gynaecological health challenges without causing harm or suspending natural reproductive functioning of the woman.

For more information on Creighton model FertilityCare & NaProTECHNOLOGY
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